A prokaryote is a cell that is more primitive than an eukaryote. A prokaryote is a cell that's only found in bacteria. An eukaryote is a more advanced cell that's found in human beings and other living things, minus bacteria. A prokaryote also doesn't have a nucleus, where as an eukaryote does. A prokaryote doesn't have any organelles, cell walls, or a nuclelosus(sp? You know what I mean, right?), but an eukaryote does. There are more differences but can't think of anymore than the obvious right now.